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百年移植:超过100年的累积脏和肝功能
Rainer W G Gruessner1, Angelika C Gruessner1
1SUNY Downstate Health Science University, 450 Clarkson Ave, NY 11203, Brooklyn.
Transplantation proceedings
|July 13, 2024
概括
移植脏和肝脏可以运行超过90年,肝脏显示延长寿命比脏更频繁. 供体和受体的选择是实现这种累积器官功能的关键.
科学领域:
- 移植免疫学 移植免疫学
- 老年医学 老年医学
- 器官移植研究 器官移植研究
背景情况:
- 移植脏和肝脏的累积寿命,考虑到捐赠者的年龄和移植后的功能,仍然不完全理解.
- 确定器官在90岁以后长期存活的潜力对于优化移植结果至关重要.
研究的目的:
- 确定移植脏和肝脏是否可以达到超过90年的累积器官功能 (COF).
- 调查影响老年捐赠者和接受者延长全移植寿命的因素.
主要方法:
- 在1987年至2022年间,对年龄≥55岁的捐赠者进行和肝移植的分析.
- 累积器官功能的计算 (COF) 作为器官捐赠时的年龄 + Tx 异位移植功能.
- 应用单变量和多变量统计方法来评估移植长寿的结果和预测因素.
主要成果:
- 16.6%的肝移植和2.7%的移植实现了90年的COF.
- 与脏相比,延长器官寿命在肝脏 (5倍) 中明显更常见.
- 最长记录的功能是108年的肝脏和104年的脏.
结论:
- 对于移植脏和肝脏,可以达到超过100个生理年的累积器官功能.
- 最佳的供体和受体选择和管理是长期全移植存活的关键预测因素.
- 仅仅捐赠者的年龄不应该是移植中和肝脏捐赠的禁忌.
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