头部和胡须运动由VPM和POm体神经元共同编码
Tess Baker Oram1, Alon Tenzer1, Inbar Saraf-Sinik1
1Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.
Nature communications
|July 13, 2024
概括
在自由移动的小鼠中,腹前后介质 (VPM) 和后介质 (POm) 乳头核同样编码胡须和头部运动. 这些大脑区域整合了感官信息,并在触觉探索期间影响头部运动.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 泰拉姆功能 泰拉姆功能
背景情况:
- 动物使用头部和胡须的运动来进行触觉感知.
- 之前在固定头部的动物上进行的研究表明,VPM和POm核编码胡须动力学,在清醒的动物中减少了POm的参与.
研究的目的:
- 为了研究VPM和POm核参与编码头部和胡须动力学在清醒,没有头部的小鼠.
- 了解这些乳头核在自然主义触觉探索中的作用.
主要方法:
- 记录了在雄性小鼠探索一个开放的竞技场的thalamic神经元活动.
- 在探索期间追踪头部和胡须的运动.
- 利用光遗传标记和激活来识别神经元群体及其功能影响.
主要成果:
- 在自由移动的小鼠中,VPM和POm核都同样编码了胡须动力学.
- 这些核强有力的编码头部动力学,增加头部动力学编码神经元后胡须修剪.
- 乳头神经元的光遗传激活诱导了动力学变化,并改变了神经元活动相对于头部运动的时间.
结论:
- 在触觉感知过程中,VPM和POm核整合了头部和胡须信息.
- 这些乳头核可以积极影响头部动力学,这表明它们在感觉运动控制中的作用.
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