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极端瘤整形:与乳腺切除术相比,在瘤学上是安全的.

Deena Hossino1,2, Melvin J Silverstein3,4, Nirav Savalia3,4

  • 1Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA. deena.hossino@gmail.com.

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与全乳腺放射治疗 (WBRT) 结合的极端瘤整形术为广泛的乳腺癌提供了与乳腺切除术相似的结果. 这种保存乳房的方法是一种可行的替代方案,在复发率或存活率上没有显著差异.

关键词:
避免进行乳房切除术.极端瘤整形术是一种极端的瘤整形术.多焦点/多中心乳腺瘤瘤塑性乳房保护方法

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科学领域:

  • 手术瘤学手术瘤学
  • 乳房手术 乳房手术
  • 辐射瘤学 辐射瘤学

背景情况:

  • 极端瘤造形术利用瘤造形技术,在通常推进行乳房切除的患者中保护乳房.
  • 指示包括多中心/多焦点瘤 (>50毫米) 或照射乳房的大型复发.

研究的目的:

  • 为了比较极端瘤整形术加全乳房放射治疗 (WBRT) 与没有WBRT的乳房切除术的结果.
  • 评估局部,区域和远程复发率,以及整体/乳腺癌特异性生存率.

主要方法:

  • 预期数据库查询 (2008-2023) 满足极端瘤整形标准的患者.
  • 使用WBRT (272名患者) 的瘤乳房整形术与不使用WBRT (101名患者) 的乳房切除术之间的比较.
  • 排除患有复发性乳腺癌的患者.

主要成果:

  • 两组之间在本地,区域或远程复发方面没有发现显著差异.
  • 在WBRT和乳腺切除组的极端瘤造形术和乳腺切除组之间,整体生存率和乳腺癌特异性生存率是可比的.
  • 随访时间中位数为7年.

结论:

  • 与WBRT结合的极端瘤整形术作为主要治疗选择得到了强烈支持.
  • 这种方法推用于适合体积位移乳房整形的大型多焦点/多中心病变的患者.
  • 它为乳房切除提供了一个可行的乳房保护替代品.