果多糖可以通过微生物群-肠-大脑轴改善与年龄相匹配的认知障碍和肠道衰老
Wenming Zhang1,2, Yuchun Zhong1,2, Zhuoya Wang3,2
1Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, 330000, Nanchang, Jiangxi, People's Republic of China.
Scientific reports
|July 13, 2024
概括
果多糖 (AP) 改善了老年小鼠的认知功能和肠道健康. 这种天然化合物增强记忆力,减少炎症和氧化应激,促进更健康的肠道微生物群,有利于整体衰老健康.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 衰老与认知能力下降和肠道功能障碍有关.
- 果多糖 (AP) 已知具有各种健康益处.
- 对AP对与衰老相关的认知和肠道变化的具体影响需要进一步研究.
研究的目的:
- 研究果多糖 (AP) 在减轻自然衰老小鼠的认知障碍和肠道衰老中的治疗潜力.
- 阐明AP对神经保护,炎症和肠道屏障功能影响的潜在机制.
主要方法:
- 老年小鼠接受了AP的治疗.
- 用莫里斯水迷宫评估认知功能.
- 分析了神经元功能 (BDNF,PSD95,SYP),氧化应激,炎症 (NF-κB通路) 和亡的分子标志物.
- 评估了肠道粘膜屏障的完整性.
- 在属级别上分析了肠道微生物群的组成.
主要成果:
- 在老年小鼠中,AP治疗显著改善了空间学习和记忆.
- AP上调关键的神经元蛋白 (BDNF,PSD95,SYP) 和增强抗氧化能力.
- AP降低了促炎性细胞因子,抑制了NF-κB激活,恢复了肠道屏障功能,降低了衰老/亡标志物.
- AP的使用调节了肠道微生物群,增加了Lactobacillus和Bacteroides,同时减少了Helicobacter和Bilophila.
结论:
- 果多糖 (AP) 在减轻小鼠认知障碍和肠道衰老方面表现出显著的有效性.
- AP具有神经保护,抗炎和抗氧化作用,同时还修复肠道屏障并改善肠道微生物群平衡.
- 这些发现表明,AP是促进健康衰老的有希望的天然化合物.
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