间通讯:在12,385名新生儿中的流行率和亚型 - - 哥本哈根婴儿心脏研究
Elisabeth Blixenkrone-Møller1,2, Sofie Dannesbo3,4,5, Anna Maria Dehn6
1Department of Cardiology, Copenhagen University Hospital Herlev, Borgmester Ib Juuls Vej 1, 2730, Copenhagen, Denmark. elisabeth.maria.blixenkrone-moeller.01@regionh.dk.
Pediatric cardiology
|July 13, 2024
概括
在新生儿中,心房间际通讯,包括 patent foramen ovale和心房隔膜缺陷,是常见的. 一种新的心声回声算法揭示了卵孔的发病率是心房隔膜缺陷的12倍.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 医疗成像医学成像
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 在新生儿中,诸如 patent foramen ovale (PFO) 和心房隔膜缺陷 (ASD) 这样的心房间际通讯是常见的.
- 以前的患病率估计 (24-92%) 由于缺乏标准化分类而有所不同.
- 一种新的心声回声算法提供了改进的诊断准确性和这些条件的分类.
研究的目的:
- 通过使用新的诊断算法,确定新生儿中不同类型的间通讯的患病率.
- 评估一项新的心声回声学分类系统在大量新生儿队列中的实用性.
主要方法:
- 在哥本哈根婴儿心脏研究中对12,385名新生儿 (0-30天) 的胸前回声图进行前性分析.
- 应用一种新的诊断算法,将心腔间通信分为PFO和ASD的亚型.
- 由于图像质量差或严重的先天性心脏病而排除了3416名新生儿.
主要成果:
- 在78.9%的研究新生儿中检测到心房间间际通讯.
- 在72.9%的新生儿中诊断出卵孔 (PFO),而在6.0%的新生儿中发现心房隔膜缺陷 (ASD).
- PFO的患病率是ASD的12倍,观察到的ASD患病率高于之前报告的.
结论:
- 在新生儿中,心房间间沟通非常普遍,PFO明显比ASD更常见.
- 新的心声回声算法为分类这些缺陷提供了一种标准化的方法.
- 需要进一步的研究来确定哪些心房间间际通讯需要临床后续或干预.
相关概念视频
01:14Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...