2型糖尿病患者的DNA甲基化衍生生物年龄和长期死亡风险
Jacopo Sabbatinelli1,2, Angelica Giuliani3, Katarzyna Malgorzata Kwiatkowska4
1Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Ancona, Italy.
Cardiovascular diabetology
|July 13, 2024
概括
通过DNA甲基化测量生物年龄的表观遗传时钟,可以预测2型糖尿病 (T2D) 患者的死亡率,而不依赖于传统的风险因素. 这种方法可以改善T2D死亡率的风险分层.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是指老年学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2D) 与已知因素之外的死亡风险增加有关.
- 使用DNA甲基化 (表观遗传钟) 来估计生物年龄是风险分层的一个潜在工具.
- 表观遗传钟对T2D患者死亡率的独立预测值仍然不清楚.
研究的目的:
- 调查表观遗传时钟是否可以独立于传统风险因素来预测T2D患者的死亡率.
- 评估基于DNA甲基化估计的衰老和T2D中的死亡率之间的关联.
- 探索DNA甲基化衍生的炎症标志物与T2D中的死亡率之间的关系.
主要方法:
- 在T2D患者队列中分析了来自外围血液白细胞的DNA甲基化.
- 利用验证的表观遗传钟 (DNAmPhenoAge,DunedinPoAm) 来估计生物年龄和衰老的速度.
- 采用两阶段的残余结果回归来评估表观遗传估计与死亡率的关联,控制风险因素.
主要成果:
- 已故的T2D受试者表现出显著更高的表观遗传年龄 (DNAmPhenoAge) 和加速的衰老速度 (DunedinPoAm).
- DNAmPhenoAge和DunedinPoAm都独立地与T2D患者的死亡风险有关.
- 在已故个体中观察到炎症蛋白 (CXCL10,CXCL11,enRAGE) 和C-反应蛋白的DNA甲基化替代品的升高.
结论:
- 根据表观遗传钟的评估,生物年龄是T2D死亡率的重要预测因素,独立于传统的风险因素.
- 基于DNA甲基化的炎症估计增加是已故T2D患者的特征.
- 需要在更大的队列中进一步验证,以确定表观遗传钟在完善T2D死亡风险预测方面的临床实用性.
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