丹麦的宫癌发病率:解开时间趋势的决定因素
Elsebeth Lynge1, Jeppe Bennekou Schroll2,3, Berit Andersen4,5
1Zealand University Hospital, University of Copenhagen, Nykøbing Falster, Denmark.
International journal of cancer
|July 14, 2024
概括
有效的宫癌控制策略,包括人类乳头瘤病毒 (HPV) 疫苗接种和改进的查,已经成功降低了丹麦的发病率,克服了以前的停滞. 这些联合干预表明,在预防宫癌方面,公共卫生取得了重大成就.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 宫癌发病率在一些资源充足的国家停滞不前,尽管这是一个可预防的疾病.
- 了解公共卫生干预措施的影响对于优化宫癌预防策略至关重要.
研究的目的:
- 调查公共卫生干预措施与丹麦宫癌发病率变化之间的关联.
- 评估人类乳头瘤病毒 (HPV) 疫苗接种和查计划对宫癌率的有效性.
主要方法:
- 对丹麦的HPV疫苗接种覆盖率,查建议和绩效以及子宫癌发病率数据的分析 (2009-2022年).
- 包括有关HPV疫苗接种覆盖率,宫细胞样本采集,HPV检测,异常结果的随访,结和发病率的数据.
- 使用了来自斯坦顿血清研究所,丹麦卫生局,宫检查丹麦质量数据库,Nordcan和丹麦癌症登记处的数据.
主要成果:
- 到2022年,高水平的HPV疫苗接种率 (80%-90%) 在29岁以下的女性中导致20-29岁年龄组的疾病消除水平 (每10万人中有3人).
- 70岁以上的女性进行一次性HPV查 (2017年推出) 大大消除了2020-2022年老年发病率的高峰.
- 查管理的改善,包括减少异常样本的随访延迟 (20%至10%),并转向基于液体的细胞学,导致发病率稳步下降.
结论:
- 儿童HPV疫苗接种,针对老年妇女的HPV查和加强查管理的联合干预措施有效地打破了宫癌发病率的停滞.
- 这些策略突显了多方面的方法在实现显著降低宫癌率方面取得的成功.
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