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Updated: Jun 21, 2025

Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications
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通过使用下一代CRISPR工具,从成年干细胞衍生的有机体中创建异源性疾病模型的协议

Martina Celotti1, Lucca L M Derks2, Johan van Es1

  • 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, 3521 AL Utrecht, the Netherlands.

STAR protocols
|July 14, 2024
PubMed
概括

这项研究引入了一种简化的协议,用于使用先进的CRISPR技术创建异构性疾病模型. 这些有机体模型有助于研究人员了解遗传变异.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?癌症 癌症 癌症 癌症遗传学 是一个遗传学.干细胞是干细胞.

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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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