稳定,ROS敏感的β-环氧素移植的色超分子纳米容器用于CD44向的抗癌药物输送
Xianshuo Zhang1, Peipei Wang1, Xinsheng Wang1
1Henan Province Key Laboratory of New Opto-electronic Functional Materials, Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, and School of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000, China.
Colloids and surfaces. B, Biointerfaces
|July 14, 2024
概括
这项研究介绍了基于氨酸的新型纳米容器,用于增强抗癌药物输送. 这些纳米药物表现出更好的稳定性和有针对性的输送,导致更大的癌细胞细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
- 在瘤学瘤学.
背景情况:
- 基于氨酸 (HA) 的纳米容器为癌症治疗提供生物相容性和CD44向.
- 现有的基于HA的纳米药物在多步合成方面面临挑战,导致变化和扩展问题.
- 需要简单和强大的战略来开发基于HA的先进纳米医学.
研究的目的:
- 开发一种简化,无添加剂的方法,用于制造稳定,响应良好的基于HA的纳米药物.
- 整合in situ交叉连接和超分子复合,以提高药物递送效率.
- 评估开发的纳米药物在向和杀死癌细胞方面的有效性.
主要方法:
- 制备具有可交叉链接的二氧化单体的二氧化单体,用于in situ交叉链接.
- 通过宿主-客人复合,制造反应性氧物种 (ROS) 敏感的超分子聚合物结构.
- 使用HA-移植HA (HA-CD) 和铁素功能化聚合物形成核心交叉连接 (CCL) 菌粒.
主要成果:
- 成功制造Fc-POEGMA/Fc-PCL-b-PDESPMA@HA-CD纳米药物,具有集成的隐形,准和交叉连接功能.
- 基于P1的CCL菌根在暴露于ROS时表现出出色的合体稳定性和细胞内聚合,促进货物释放.
- 与CD44阴性MCF-7细胞相比,基于P1的纳米药物在CD44阳性HeLa细胞中显示出增强的细胞毒性.
结论:
- 开发了基于HA的纳米药物的简单策略,使用in situ交叉链接和超分子复杂化.
- 这些纳米药物具有卓越的细胞外稳定性和高效的细胞内不稳定性,可以改善药物输送.
- 这种方法为增强的抗癌疗法提供了一个有前途的平台,减少了批次对批次的变化.
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