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Updated: Jun 21, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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通过外部和线粒体通路设计和合成具有抗瘤活性的6,20-环氧A环修饰的欧里多宁衍生物,通过外部和线粒体通路进行抗瘤活性

Haonan Li1, Xiaogang Luo1, Feilong Zhu2

  • 1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.

Bioorganic chemistry
|July 14, 2024
PubMed
概括

一种新型的奥里多宁衍生物,EpskA21,通过通过线粒体和外部途径诱导亡,表现出强大的抗瘤活性. 这种化合物有效地抑制癌细胞的增殖和迁移,提供了一个有前途的新疗法候选者.

关键词:
这是一种抗瘤药物.细胞灭亡 (apoptosis) 是一种死亡的过程.恩特 - 考拉尼 (Ent-kaurane) 是一个甲基氨酸的使用方法结构修改是指结构的修改.

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