间歇性禁食,卡路里限制和性饮食通过减少肥胖期间单细胞中的脂多糖体信号传递来改善线粒体功能:一项随机临床试验
Martha Guevara-Cruz1, Karla G Hernández-Gómez1, Citlally Condado-Huerta1
1Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico.
Clinical nutrition (Edinburgh, Scotland)
|July 14, 2024
概括
卡路里限制,间歇性禁食和性饮食通过改变肠道微生物群来改善肥胖症中的单细胞线粒体功能. 这些饮食变化可以减少炎症,增强新陈代谢健康.
科学领域:
- 代谢健康 代谢健康
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 单细胞中的线粒体功能障碍有助于与肥胖有关的炎症.
- 饮食干预是治疗肥胖症的关键,但它们对单细胞生物能量的影响尚不清楚.
研究的目的:
- 评估卡路里限制 (CR),间歇性禁食 (IF) 和性饮食 (KD) 对单细胞线粒体功能的影响.
- 研究肠道微生物群调节在这些影响中的作用.
主要方法:
- 随机对照试验4组 (CR,IF,KD,随意习惯饮食) 2个月.
- 分析了单细胞氧气消耗率 (OCR) 和肠道微生物群组成.
- 测量了人体测量,生化参数和血清脂多糖化物 (LPS) 水平.
主要成果:
- 与ad libitum组相比,单细胞中的CR,IF和KD增加了最大呼吸OCR.
- 这些饮食改善了线粒体功能,减少了单细胞糖解的依赖性.
- 饮食和利法西明增加了肠道微生物群的多样性,并调节了特定的细菌丰度,减少了产生LPS的细菌.
结论:
- 饮食干预 (CR,IF,KD) 在肥胖个体的单细胞中增强线粒体的生物能量健康.
- 肠道微生物群调节在这些改善中起着关键作用.
- 单细胞线粒体功能可以作为代谢和炎症状态的生物标志物.
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