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Updated: Jun 21, 2025

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
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在三阴性乳腺癌中,M2巨细胞通过分泌CXCL1促进PD-L1的表达

Lifen Zhang1, Shanzhi Gu2, Lu Wang1

  • 1Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Pathology, research and practice
|July 14, 2024
PubMed
概括

通过通过CXCL1信号传递增加PD-L1表达,M2巨细胞促进三阴性乳腺癌 (TNBC) 的进展. 向M2巨细胞和CXCL1可能为TNBC提供新的治疗策略.

关键词:
一个C-X-C动图的化学基因连接体1 1在瘤免疫学上.编程死亡联手 1 编程死亡联手 1三阴性乳腺癌是三阴性乳腺癌.与瘤相关的巨细胞.

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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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