Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cancer-Associated STAT3 Mutations Maintain ES Cell Self-Renewal Through Phosphorylation-Independent Mechanisms.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same author

Surgical Safety after Preoperative Chemotherapy for Perihilar Cholangiocarcinoma: Multi-Institutional Propensity-Matched Analysis.

Annals of surgical oncology·2026
Same author

Feasibility of Surgical Resection for Advanced Gallbladder Carcinoma Based on Preoperative Clinical T Stagings: A Multicenter Retrospective Analysis (SNOW-22-05).

Journal of hepato-biliary-pancreatic sciences·2026
Same author

Towards sustainable hereditary breast and ovarian cancer surveillance: insights from a single-center survey.

Journal of human genetics·2026
Same author

Selective Postmortem Marbling in the Upper Body: A Case of Cardiac Tamponade.

The Tokai journal of experimental and clinical medicine·2026
Same author

Effects of oxidative stress and aging on nerve, muscle, and synapse in a male-specific abdominal neuromuscular junction in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 21, 2025

Quantitative Analysis of Chromatin Proteomes in Disease
08:11

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

13.1K

人类正常心脏的层特异性蛋白质基因分析.

Yu Kakimoto1, Atsushi Ueda1, Yayoi Kimura2

  • 1Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa 259-1193, Japan.

Pathology, research and practice
|July 14, 2024
PubMed
概括

这项研究揭示了人类心脏层中的独特蛋白质配置,识别了可能解释心脏异型功能的活性丝结合蛋白. 这项研究提供了关于心脏健康和疾病的见解.

关键词:
在 CTNNA3 中.人类的心脏 人类的心脏这就是MYH1的原因.心肌层是心肌层中的一个层.蛋白质组学是指蛋白质组学.跨村异质性 跨村异质性

更多相关视频

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion
07:54

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Published on: August 29, 2018

8.6K
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

12.9K

相关实验视频

Last Updated: Jun 21, 2025

Quantitative Analysis of Chromatin Proteomes in Disease
08:11

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

13.1K
Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion
07:54

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Published on: August 29, 2018

8.6K
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

12.9K

科学领域:

  • 心血管生物学 心血管生物学
  • 蛋白质组学是指蛋白质组学.
  • 心脏解剖学 心脏解剖学

背景情况:

  • 心肌层 (内部纵向,中间圆形,外部纵向) 对于血液循环至关重要.
  • 之前的研究缺乏对人类心脏组织的层特异性蛋白质组数据.

研究的目的:

  • 为了确定人类心脏中单个心肌层的独特蛋白质结构.
  • 研究这些蛋白质在心脏功能中的作用.

主要方法:

  • 从三种不同的左心室心肌层中微切除心肌细胞.
  • 枪支蛋白质基因分析和组织学分析.
  • 蛋白质定位的免疫组织化学分析.

主要成果:

  • 鉴定了1220种蛋白质,其中92种蛋白质显示出显著的层特异性表达差异.
  • 在内和外层上升的蛋白质主要是actin线索结合蛋白.
  • MYH1和CTNNA3分别在外层和内层显示出高特异性表达.

结论:

  • 这是正常人心脏的第一个层特异性蛋白质组概况.
  • 动氨酸结合蛋白的异性otropic 分布可能有助于心脏收缩和导电异性otropy.
  • 了解这些概况有助于研究心脏病理和治疗,包括心肌梗塞.