异常的大脑功能连接介导负面症状对精神分裂症认知功能的影响:结构方程模型
Jin Fang1, Renliang Cai1, Yunshan Hu1
1Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Journal of psychiatric research
|July 14, 2024
概括
大脑连接影响负面症状如何影响精神分裂症的认知功能. 特定大脑区域之间的异常功能连接调解了这些影响,为治疗策略提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症呈现出积极的症状,消极的症状和认知缺陷.
- 了解消极症状和认知缺陷背后的机制对于改善精神分裂症治疗和预后至关重要.
- 异常的大脑功能连接被假设为介导负面症状和认知障碍之间的关系.
研究的目的:
- 研究负面症状对精神分裂症患者认知功能的间接影响.
- 探索异常功能连接作为这种关系中介者的作用.
主要方法:
- 招募了150名男性精神分裂症患者和108名健康对照.
- 负面症状使用简要负面症状量表进行评估,分为动机和快乐缺陷 (MAP) 和表达力下降 (EXP).
- 使用神经认知测试评估认知功能,并分析休息状态fMRI数据以构建功能连接网络. 使用结构方程建模来分析相互作用.
主要成果:
- 动机和快乐缺陷 (MAP) 显著损害了认知功能.
- 左侧胰岛与左侧前骨之间的功能连接,以及左侧前骨与右角骨之间的功能连接,充当中间体.
- 这些连接模式调解了MAP和EXP对认知功能的间接影响.
结论:
- 异常的大脑功能连接在精神分裂症中负面症状和认知功能之间的关系中起到缓和作用.
- 这些发现提供了关于精神分裂症负面症状和认知缺陷的神经支的见解.
- 识别这些神经相关物可能会为未来的治疗干预提供信息.
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