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Updated: Jun 21, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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发现了双价小分子降解酶7 (CDK7) 的双价小分子降解剂

Wenzhi Ji1, Guangyan Du2, Jie Jiang2

  • 1Department of Chemical and Systems Biology, Chem-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, 94305, USA.

European journal of medicinal chemistry
|July 14, 2024
PubMed
概括

使用新型化合物JWZ-5-13向林依赖激酶7 (CDK7) 的向蛋白降解有效降解CDK7,抑制癌细胞增殖,并显示在小鼠中的生物可用性.

关键词:
CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7 CDK7这就是PROTAC.蛋白质降解剂可以降解蛋白质.选择性的 选择性的 选择性的

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