单次暴露于来自食品的聚乙烯和聚烯微塑料对体外结肠模型中的肠道微生物群产生了深刻的影响
Lorenzo Nissen1, Enzo Spisni2, Renato Spigarelli3
1DiSTAL - Department of Agricultural and Food Sciences, Alma Mater Studiorum - University of Bologna, P.za G. Goidanich, 60 47521, Cesena, Italy; CIRI - Interdepartmental Centre of Agri-Food Industrial Research, Alma Mater Studiorum - University of Bologna, P.za G. Goidanich, 60 47521, Cesena, Italy; CRBA, Centre for Applied Biomedical Research, Alma Mater Studiorum - University of Bologna, Policlinico di Sant'Orsola, Bologna 40100, Italy.
Environment international
|July 14, 2024
概括
食品中的微塑料破坏了肠道微生物群,导致机会性细菌过度生长,有益的微生物减少. 这种一次性食物暴露显著改变了人类的结肠微生物群生态和代谢功能.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是食品和饮料中普遍存在的环境污染物.
- 人类摄入MPs是一个日益严重的公共卫生问题,特别是影响胃肠道系统.
- 暴露于MP可以改变肠道生理学,首先是肠道微生物组的变化.
研究的目的:
- 调查一次摄入聚乙烯 (PE) 和聚烯 (PS) MPs 对健康志愿者的结肠微生物群的影响.
- 用体外肠道模型分析微生物生态和代谢活动的变化.
- 评估食品衍生MP负载对人类肠道微生物群的影响.
主要方法:
- 为了研究国会议员的影响,采用了奥米克方法.
- 使用INFOGEST系统对PE和PSMP的混合物进行了消化.
- 消化的MPs在多单元体外结肠模型 (MICODE) 中与人类便微生物群发酵.
主要成果:
- 观察到结肠微生物群组成的显著变化.
- 机会性细菌 (Enterobacteriaceae,Desulfovibrio spp.,Clostridium I组,Atopobium - Collinsella组) 显示出过度生长的情况.
- 除了乳杆菌类外,有益细菌种群的数量减少,与代谢活动的改变相关.
结论:
- 一顿饭的PE和PS微塑料可以显著改变人类结肠微生物群的生态平衡.
- 暴露于MP会促进潜在有害细菌的生长,同时抑制有益细菌的生长.
- 微生物群组成的这些变化与细菌代谢功能的变化有关,突出显示了潜在的健康风险.
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