鼻喷雾剂和行为干预措施与初级保健中急性呼吸道疾病的常规护理相比:一个随机,受控,开放标签,并行组试验
Paul Little1, Jane Vennik1, Kate Rumsby1
1Primary Care Research Centre, University of Southampton, Southampton, UK.
The Lancet. Respiratory medicine
|July 14, 2024
概括
鼻喷雾剂,无论是基于凝的还是盐水的,都显著减少了呼吸系统疾病的持续时间. 所有经过测试的干预措施,包括一个行为网站,与通常护理相比,也降低了抗生素的使用.
科学领域:
- 呼吸系统健康 呼吸系统健康
- 公共卫生干预措施 公共卫生干预措施
- 临床试验 临床试验
背景情况:
- 有限的证据表明,鼻喷雾或行为干预可以缩短呼吸道感染.
- 这项研究调查了鼻喷雾剂和数字行为干预措施对呼吸系统疾病常规护理的疗效.
研究的目的:
- 评估基于凝的鼻喷雾剂,盐酸鼻喷雾剂以及身体活动/压力管理网站对呼吸系统疾病持续时间的影响.
- 将这些干预措施与英国全科医生环境中的通常护理进行比较.
主要方法:
- 一个随机的,受控的,开放的标签试验,涉及13,799名患有风险因素或频繁呼吸道感染的成年人.
- 参与者被分配到通常的护理,基于凝的喷雾,盐水喷雾或行为网站干预.
- 主要结局:6个月的病日总数;次要结局:不良事件和抗生素使用.
主要成果:
- 基于凝 (6.5天) 和盐酸鼻喷雾 (6.4天) 均显著减少了与通常护理 (8.2天) 相比的疾病持续时间.
- 行为网站干预并没有显著减少疾病持续时间 (7.4天).
- 所有干预措施都减少了抗生素的使用;然而,基于凝的喷雾组报告了更多的头痛/鼻疼痛.
结论:
- 鼻喷雾剂 (基于凝和盐水) 有效地缩短呼吸系统疾病的持续时间.
- 所有干预措施,包括行为网站,减少了抗生素的使用,这表明有可能广泛实施.
- 建议进行进一步的研究,以探索这些简单干预措施的广泛应用.
更多相关视频
07:28Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
40.7K
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
30.2K
相关概念视频
Drugs Used in Upper Respiratory Disorders: Overview
209
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
209
Inhaled Medications
249
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
249
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Drugs Used in Lower Respiratory Disorders: Overview
397
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
397
Drug Delivery: Miscellaneous Routes
336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336
Operant Conditioning Intervention
56
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
In operant conditioning, behaviors that are...
56
