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在高血糖期间,RIPK1对于β细胞的细胞死亡调节是不可或缺的

Önay Veli1, Öykü Kaya1, Ana Beatriz Varanda2

  • 1Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.

Molecular metabolism
|July 14, 2024
PubMed
概括

受体相互作用蛋白激酶1 (RIPK1) 不调节胰腺β细胞的细胞死亡,即使在糖尿病期间. 贝塔细胞主要通过独立于RIPK1的瘤坏死因子 (TNF) 经历卡斯巴酶依赖的死亡,并受到cFLIP的保护.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.糖尿病 糖尿病 糖尿病尸体灭 (Necroptosis) 是一种死亡的过程.在RIPK1中使用.这就是TNF TNF.cFLIPIP 的意思是FLIP.的β细胞.

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