在先天性红疹综合征的婴儿期内进行的白内障手术后的二级玻璃眼:一个病例对照研究
Gayathri J Panicker1, Sumita Agarkar1, Mona Khurana2
1Pediatric Ophthalmology and Strabismus Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.
Ophthalmology. Glaucoma
|July 14, 2024
概括
与其他婴儿白内障相比,患有先天性红疹综合征 (CRS) 的儿童接受白内障手术的二次绿内障发生率与其他婴儿白内障相似. 然而,在CRS患者中,长期没有青光眼的生存率较低,因此需要更密切的监测.
科学领域:
- 眼科医生 眼科 眼科
- 儿科手术 儿科手术
- 遗传学和先天性疾病
背景情况:
- 先天性红疹综合征 (CRS) 可以导致婴儿白内障,需要手术干预.
- 二次性绿内障是婴儿白内障手术后的潜在并发症.
- 在CRS患者中,风险因素和二次眼的比较发病率尚未完全阐明.
研究的目的:
- 为了比较患有CRS的儿童在婴儿白内障手术后发生的二次绿内障的发病率与非红内障的白内障.
- 为了确定与这些儿科群体中二次青光瘤的发展相关的风险因素.
主要方法:
- 追溯病例控制研究设计.
- 包括接受白内障手术的婴儿,将CRS病例与年龄匹配的非红疹白内障对照进行比较.
- 青光眼发病率和生存概率的比较,随访时间至少为1年.
主要成果:
- 在CRS和对照组之间手术时的平均年龄没有显著差异.
- 在14年的时间里,二次性玻璃眼的累积发病率在CRS中为32.7%,在对照组中为24.5% (P=0.19).
- 在CRS组显著降低了10年无眼生存率 (0.53比0.8;P=0.034). 微是CRS眼睛的一个危险因素 (HR 2.83,P=0.002).
结论:
- 在CRS和非红疹组之间,婴儿白内障手术后二次绿内障的发生率类似.
- 患有CRS的儿童在手术后10年内仍然没有青光眼的概率显著降低.
- 建议对所有接受白内障手术的婴儿进行扩大和警的随访,特别是那些患有CRS和微等危险特征的婴儿.
相关概念视频
01:25Glaucoma: Overview
538
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
538
01:28Angle Closure Glaucoma: Treatment
470
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
470
01:27Open Angle Glaucoma: Treatment
427
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
427
01:22Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K