相关实验视频

Updated: Jun 21, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

开发和验证在免疫治疗期间患者甲状腺功能障碍的预测模型

Qian Wang¹, Tingting Wu¹, Ru Zhao²

¹Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|July 14, 2024

概括

这项研究开发了一个名图,用于预测免疫检查点抑制剂对甲状腺的毒性. 该模型准确地识别了有风险的患者,帮助针对甲状腺免疫相关不良事件的个性化治疗决策.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

免疫检查点抑制剂 (ICI),如PD-1/PD-L1抑制剂,可以引起与免疫相关的不良事件 (irAEs).
甲状腺功能障碍是与ICI治疗相关的显著的irAE.
需要预测模型来识别患有ICI诱导甲状腺毒性风险的患者.

研究的目的:

开发和验证一种预测模型,用于评估ICI治疗患者甲状腺毒性风险.
为了确定甲状腺irAEs的关键预测因素.
为临床风险评估创建一个直观的工具.

主要方法:

对586名接受PD-1/PD-L1抑制剂治疗的患者进行了回顾性分析.
在培训队列 (70%) 上使用后勤回归的预测模型的开发.
内部验证使用K折交叉验证对验证队列 (30%),评估歧视和校准.

主要成果:

开发了一种纳米图,其中包含了基线甲状腺激素 (TSH),甲状腺蛋白抗体 (TgAb),甲状腺过氧化酶抗体 (TPOAb) 和血小板计数.
该模型显示出优异的歧视,AUC为0.863 (培训) 和0.885 (验证).
校准曲线显示很适合,决策曲线分析证实了临床效用.

结论:

开发的诺米图是预测接受ICI的患者甲状腺irrAEs的有效工具.
这个工具帮助临床医生做出个性化治疗决策.
早期识别有风险的患者可能会减轻甲状腺毒性.

关键词:

免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件甲状腺功能障碍甲状腺功能障碍

更多相关视频

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...