双A:对男性生殖系统和男性后代的表观遗传影响
Zhilin Hong1, Yingpei Xu2, Jinxiang Wu3
1The center of clinical laboratory, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, PR China.
双甲 (BPA) 暴露会通过改变诸如DNA甲基化等表观遗传标记来影响男性生殖健康. 这些由BPA引起的变化会影响生育能力,并传给后代.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 双A (BPA) 是一种广泛使用的工业化学物质,已知有毒性作用.
- 表观遗传修饰对于调节基因表达和生殖功能至关重要.
- 男性生殖系统的表观遗传模式改变会损害生育能力,并具有遗传性.
研究的目的:
- 审查双A (BPA) 暴露对男性生殖系统内表观遗传标记物的影响.
- 为了检查BPA如何影响DNA甲基化,基因素修饰和非编码RNAs.
- 评估BPA暴露对男性生殖功能及其跨代影响的后果.
主要方法:
- 对调查BPA和男性生殖表观遗传学的研究进行文献综述.
- 对BPA诱导的DNA甲基化变化研究的分析.
- 综合了关于BPA对基因素修饰和非编码RNA的影响的发现.
- 检查详细说明BPA对男性生殖功能和后代表观遗传学影响的研究.
主要成果:
- 暴露于BPA与男性生殖系统内DNA甲基化模式的显著改变有关.
- 基斯修饰和非编码RNA表达也受到BPA的影响,导致生殖功能障碍.
- 这些由BPA诱导的父子表观遗传变化可以传递给他们的后代,可能会影响他们的健康.
- 对男性生殖功能 (包括生育能力) 的不良影响与BPA介导的表观遗传干扰有关.
结论:
- 通过表观遗传破坏,BPA暴露对男性生殖健康构成风险.
- 胚胎细胞的表观遗传修饰是BPA毒性和跨代遗传的关键媒介.
- 需要进一步的研究才能充分了解BPA对男性生殖和后代健康的表观遗传影响的范围.
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