双剂量乌利普里斯塔酸对肥胖个体的紧急避孕:一个随机交叉试验
Alison Edelman1, Jon D Hennebold2,3, Kise Bond2
1Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, USA edelmana@ohsu.edu.
BMJ sexual & reproductive health
|July 14, 2024
概括
一个标准的30mg剂量乌利普里斯塔酸 (UPA) 紧急避孕 (EC) 有效地延迟了肥胖个体的排卵. 将UPA剂量增加到60mg不会改善结果,也不建议根据身体大小调整剂量.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学是指药理学的学科.
- 肥胖医学 肥胖医学
背景情况:
- 肥胖会影响紧急避孕药的药理动力学和药理动力学.
- 乌利普里斯塔酸 (UPA) 是一种常用的EC,但其在肥胖患者中的有效性需要进一步研究.
- 在不同人群中了解UPA的最佳剂量策略对于生殖健康至关重要.
研究的目的:
- 评估是否增加含有乌利普里斯塔酸盐 (UPA) 的紧急避孕药 (EC) 的剂量可以提高肥胖患者的药理学结果.
- 为了比较30mg与60mgUPA在延迟排卵的有效性,女性的体重指数 (BMI) >30kg/m2.
- 评估UPA剂量对肥胖参与者的卵泡破裂和激素水平的影响.
主要方法:
- 一项随机交叉研究,涉及健康,经常骑自行车的女性,BMI>30 kg/m2,体重>80 kg.
- 参与者接受了30毫克或60毫克口服UPA EC,在两个周期的随机序列中,通过阴道超声波和血液采样进行激素分析.
- 对照组BMI<25 kg/m2接受了30mg的UPA以进行比较.
主要成果:
- 在肥胖个体中,30mg和60mg的UPA剂量在延迟卵泡破裂方面表现出高效率 (分别为96%和91%).
- 与30mg剂量相比,60mg剂量导致UPA及其活性代谢物度增加了两倍.
- 所有参与者都经历了至少5天的卵泡破裂延迟,当UPA在LH激增之前被管理时.
结论:
- 标准30mg的乌利普里斯塔酸 (UPA) 剂量足以延迟个体的排卵,无论他们的BMI或体重如何.
- 研究结果不支持在紧急避孕中根据身体大小调整UPA剂量.
- 30mg的UPA剂量有效用于肥胖妇女的紧急避孕,保持其药理动力学特征.
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
156
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156
Insulin: Dosing Regimen and Adverse Effects
165
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
165
Drugs for Treatment of Constipation-Predominant IBS
154
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
154
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
119
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
119
Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K


