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挥发性有机化合物暴露与牙周炎之间的关联:一个代表性的横截面研究

Haitao Dong¹, Xueting Wang^2,3, Ning Xiao¹

¹Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of clinical periodontology

|July 14, 2024

概括

暴露于像1,4-二二这样的挥发性有机化合物 (VOC) 与牙周炎风险增加有关. 总 bilirubin 可能会调解这种关联,突出显示环境污染是一个公共卫生问题.

科学领域:

环境健康环境健康
口腔健康口腔健康
毒理学毒理学毒理学

背景情况:

牙周炎是一种常见的口腔疾病,是成年人牙脱落的主要原因.
环境污染与牙周炎有关,但挥发性有机化合物 (VOC) 的作用尚未得到充分研究.

研究的目的:

调查血液中VOC水平与牙周炎患病率之间的关联.
确定与牙周炎相关的特定VOC,并探索潜在的介导因素.

主要方法:

使用国家健康和营养检查调查 (NHANES) 数据 (2011-2014) 的横截面研究.
在2772名参与者的血液中分析VOC度和牙周炎.
使用了加权后勤回归,受限立方线 (RCS) 和加权量子素总和 (WQS) 回归模型.

主要成果:

增加的1,4-二二烯水平与患牙周炎的概率增加了16%.
1,4-二二是同时暴露的VOC和牙周炎之间的关联的主要贡献者.
总白血素介导了1,4-二二和牙周炎之间的关联的4.32%;o-xylene的影响在年轻人 (<65) 中更强烈.

结论:

这项研究提供了将特定的VOC,特别是1,4-二二与牙周炎联系在一起的证据.
暴露于挥发性有机物是一个公共卫生问题,需要进一步研究将挥发性有机物与牙周炎联系在一起的机制.

关键词:

流行病学流行病学一般的健康状况.牙周炎是指牙周炎的一种疾病.

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