手术前激素刺激对尿道板的影响; 组织学和组织化学研究
Michael Sennert1, Christina Perske2, Mohammed Fawzy1
1Hypospadias Centre, Department of Pediatric Surgery, Emma and Sana Klinikum Offenbach Hospitals, Germany.
Journal of pediatric urology
|July 14, 2024
概括
在手术前的激素刺激 (PHS) 显著增加了尿道板中的血管密度和直径,用于低血压手术. 这种增强的血管性可能有助于降低受影响儿童的状脉动严重程度.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 儿科手术 儿科手术
- 发展生物学 发展生物学
背景情况:
- 术前激素刺激 (PHS) 用于增强阴茎大小和化品结果在hypospadias修复.
- PHS对阴茎组织,特别是尿道板的确切影响仍然不完全理解.
- 之前的研究表明,PHS增加了前皮的血管性,但其对尿道板的影响没有被检查.
研究的目的:
- 为了研究PHS对尿道板的影响,在儿童中严重的hypospadias和chordee.
- 确定PHS是否影响尿道板的血管性和组织学特征.
- 为了建立一个基线理解PHS在hypospadias手术中的潜在治疗应用.
主要方法:
- 一项比较性研究涉及16名患有近端/周围皮缺血症和严重带症的儿童.
- 组A (8名儿童) 接受了手术前的PHS;组B (8名儿童) 作为没有PHS的对照.
- 尿道板和底层组织样本使用组织学染料 (血素-素,弹性范-吉森) 和免疫组织化学 (因子8,SMA) 进行分析.
主要成果:
- 与对照组 (B组) 相比,接受PHS (A组) 的儿童的血管密度 (82 vs. 65血管/mm2) 和血管直径 (13 μm vs. 11 μm) 的中位数显著更高.
- 虽然上皮层厚度在A组 (110微米比98微米) 较大,但这种差异在统计学上并不显著.
- 没有观察到dartos带膜厚度,雄激素受体表达或弹性纤维组织的显著变化.
结论:
- 这项研究提供了第一个证据,即PHS显著提高了小便道板内的血管密度和直径,在患有严重带的儿科低血压病例中.
- 观察到的血管性增加表明,PHS可能有助于改善手术纠正前的组织质量.
- 这些发现支持PHS的潜在使用,以增强血管性和潜在地减轻在hypospadias手术中chordee的严重程度.
相关概念视频
Hormonal Regulation of the Menstrual Cycle
338
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
338
Hormonal Control of the Ovarian Cycle
461
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
461
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
Target Cell Response to Hormones
3.0K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.0K


