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Updated: Jun 21, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Published on: April 28, 2021

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PARPi,BRCA和差距:争议和未来的研究

Diego Dibitetto1, Carmen A Widmer2, Sven Rottenberg3

  • 1Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland; Bern Center for Precision Medicine and Cancer Therapy Research Cluster, Department for Biomedical Research, University of Bern, 3012 Bern, Switzerland; Molecular Oncology and DNA Damage Response Laboratory, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.

Trends in cancer
|July 14, 2024
PubMed
概括

聚 ((ADP-ribose) 聚合酶抑制剂 (PARPis) 通过利用同源重组缺陷来提供癌症治疗. 这篇综述考察了PARPi机制,DNA聚合酶甲基.

关键词:
这就是BRCA BRCA.造成的DNA损伤是DNA损伤.在 PARP 抑制剂.癌症 癌症 癌症 癌症 癌症差距 差距 差距 差距 差距同类的重组组合.

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