[在医疗紧急情况下进行舌下和口腔药物管理]
Joan Ramon Roma1, Pedro Castro Rebollo2, Carla Bastida1
1Servicio de Farmacia, Área del Medicamento, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España.
概括
在口服或静脉注射途径失败的情况下,在紧急情况下,口服和口服药物给药提供了快速的治疗效果. 本综述强调了他们在重症监护场景中的好处和挑战.
科学领域:
- 药理学和急救医学 药理学和急救医学
- 药物输送系统 药物输送系统
背景情况:
- 有效的药物管理对于治疗成功至关重要.
- 传统的途径 (口服,静脉注射) 在医疗紧急情况下并不总是可行的.
- 需要其他途径来快速输送药物.
研究的目的:
- 审查在医疗紧急情况下对舌下和口腔药物管理的证据.
- 探索应用于心血管紧急情况,急性疼痛,激动和状态的应用.
- 介绍这些路线的优点,缺点和未来前景.
主要方法:
- 现有证据的叙述性审查.
- 将证据分类为紧急情况.
- 分析语言下和口腔路线的好处和缺点.
主要成果:
- 舌下和口腔途径为快速药物输送提供了可行的替代方案.
- 证据支持在心血管紧急情况,疼痛管理,激动控制和发作中使用它们.
- 关键的优势包括迅速发病和避免第一通代谢.
结论:
- 舌下和口腔注射在紧急情况下是有价值的.
- 进一步的研究和开发可以优化这些药物输送系统.
- 这些路线为传统药物管理方法提供了有希望的替代方案.
相关概念视频
Drug Delivery: Enteral Route
415
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
415
Routes of Drug Administration: Enteral
3.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.4K
Routes of Drug Administration: Overview
6.1K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.1K
Non-Oral Extravascular Drug Absorption Routes
209
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
209
Additional Routes of Drug Administration
2.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.7K
Drug Delivery: Miscellaneous Routes
336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336


