初级甲状腺功能障碍症中神经精神疾病的风险:甲状腺切除术与非手术治疗相比
Zhixing Song1, Sanjana Balachandra1, Christopher Wu1
1Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
World journal of surgery
|July 14, 2024
概括
副甲状腺切除术可以改善原发性副甲状腺症 (PHPT) 患者的神经精神症状. 手术降低了认知障碍,精神分裂症和昏昏欲睡的风险,表明了手术的好处.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 精神病学是一个精神病学.
背景情况:
- 原发性偏甲状腺症 (PHPT) 与神经精神疾病有关.
- 副甲状腺切除术对这些症状的疗效仍在争论中.
研究的目的:
- 为了比较经过副甲状腺切除术的PHPT患者中神经精神疾病发病率与非手术治疗.
主要方法:
- 对3728名PHPT患者的回顾性审查.
- 倾向性得分匹配和考克斯回归分析.
- 随访时间中位数为4.2年.
主要成果:
- 副甲状腺切除术降低了认知障碍 (HR 0.65),精神分裂症 (HR 0.08) 和嗜睡 (HR 0.45) 的风险.
- 对于焦虑,抑郁或自杀念头没有显著差异.
- 手术患者对神经精神疾病的住院治疗率较低 (0.3%对1.8%).
结论:
- 副甲状腺切除术与特定神经精神疾病的风险降低有关.
- 操作管理可能有利于PHPT患者的神经精神症状.
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