精神分裂症患者在未服用药物和服用药物的个体中神经解剖学和认知之间的多变量关联
Qiannan Zhao1,2,3, Ziyang Gao1,2,3, Wei Yu1,2,3
1Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Schizophrenia (Heidelberg, Germany)
|July 14, 2024
概括
精神分裂症患者表现出不同的大脑认知联系,这取决于药物状态. 没有药物治疗的患者将thalamic体积与认知联系起来,而服用药物治疗的患者显示出与记忆和注意力相关的不同模式.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 以前关于精神分裂症神经解剖学和认知的单变量研究产生了不一致的结果.
- 抗精神病药物对精神分裂症患者大脑行为关系的影响尚不清楚.
- 该研究解决了需要区分神经解剖学-认知协会在药物治疗与非药物治疗的精神分裂症患者.
研究的目的:
- 为了研究精神分裂症患者的多变量神经解剖学-认知关系,无论是先前服用药物还是接受过抗精神病治疗的个体.
- 为了确定每个患者群体特有的独特的大脑行为模式.
主要方法:
- 包括59名以前没有服用过药物的精神分裂症患者和115名接受过抗精神病治疗的精神分裂症患者.
- 多变量建模将认知领域与神经解剖学特征 (皮质厚度,皮质表面积,皮质下体积) 相关联.
- 对成像质量,疾病持续时间,抗精神病剂量和精神病理学进行控制的分析.
主要成果:
- 在FES和治疗精神分裂症样本之间观察到明显的多变量相关性模式.
- 在FES患者中,在运动,符号编码和口头流方面表现更好,与较大的乳头体积和较低的前额/前带皮质皮层厚度有关.
- 在接受治疗的患者中,较差的口头记忆与较小的皮下体积和状/状皮层表面积相关;较低的符号编码得分与准海马环和尾状核的特定变化相关.
结论:
- 精神分裂症中神经解剖学-认知关联是样本特定的,在未药物和药物治疗的个体之间有所不同.
- 研究结果强调了抗精神病治疗对大脑行为特征的潜在影响.
- 结果可能有助于对认知障碍的理解,并指导开发针对精神分裂症的有针对性的干预措施.
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