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在局部晚期宫癌中对新辅助化疗的病理反应的评估

Li-Jun Wei^1,2, Jia Fu^1,2, Hai-Xia Yang^1,3

¹State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

Journal of translational medicine

|July 14, 2024

概括

在局部晚期宫癌 (LACC) 中,新辅助化疗 (NACT) 反应更好地通过治疗前瘤透淋巴细胞体积 (TILV) 预测. 一个新的分级系统还确定了树叶类型作为NACT后的关键预后因素.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

新辅助化疗 (NACT) 是局部晚期宫癌 (LACC) 的标准治疗方法.
在LACC中对NACT的病理反应的预测因素仍然不完全理解.
组织学特征和免疫细胞透是治疗疗效的潜在指标.

研究的目的:

确定影响LACC患者对NACT病理反应的因素.
开发一种新的病理学分级系统,用于评估治疗反应和预后.
评估免疫细胞透和树皮特征的预后意义.

主要方法:

收集了来自185名LACC患者的瘤样本,这些样本是在NACT前后收集的.
在预处理组织上进行了组织学评估和免疫基因表达分析.
开发了一种基于瘤活力,炎症,纤维化和死的新型病理分级系统.

主要成果:

72.4%的患者获得了对NACT.的良好病理反应 (GPR).
治疗前瘤透淋巴细胞 (TILs) 和TIL体积 (TILV) 的增加与GPR相关;TILV是一个独立的预测因子.
在GPR患者中,CD8+ T细胞数量较高,FOXP3+ T细胞数量较低;GPR和炎症类型预测了更好的生存率;树突类型是一个独立的预后因素.

结论:

治疗前提升的TILV可能预测LACC中对NACT的良好反应.
一个新的病理学分级系统,包括 stromal 类型的后期治疗,有助于预后评估.
这种分级系统提供了对LACC中NACT反应和患者结果的全面了解.

关键词:

在局部晚期的宫癌.新辅助化学疗法新辅助化学疗法病理反应是一种病理反应.预测预后预测预测流体类型流体类型

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