治疗和遗传分析多个超数和冲击牙在一个青少年患者的病人
Panjun Pu1,2, Yuxia Hou1,2, Qing Zhang1,2
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, No. 98, Xiwu Road, Xincheng District, Xi'an, Shaanxi, 710004, PR China.
BMC oral health
|July 14, 2024
概括
这项研究详细介绍了一名12岁男孩成功接受了正牙治疗,该男孩有多个超数和受影响的牙. 基因分析确定了TCF7L2基因变异与这种疾病之间的潜在联系,为非综合征超数牙提供了洞察力.
科学领域:
- 牙科 牙科是指牙科的专业.
- 遗传学 是一个遗传学.
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- 多个超数和受冲击的牙会导致复杂的缺陷和治疗挑战.
- 这些牙异常的非综合征病例的遗传基础在很大程度上仍未知.
研究的目的:
- 报告一个患有多个超数和冲击牙的患者的正义牙科管理的成功.
- 通过综合性分析,调查非综合征超数牙的潜在遗传病因.
主要方法:
- ортодонтическое治疗涉及抽取15颗牙和应用的闭式喷发和绕道门技术.
- 在患者和父母身上进行全外体测序,以确定遗传变异.
- 对治疗结果的临床评估,包括牙对齐,塞和牙周健康状况.
主要成果:
- 所有受冲击的牙的成功引,没有任何并发症.
- 在治疗后获得了优异的空间封闭,牙对齐和功能性闭塞.
- 整个外体序列测定揭示了TCF7L2基因中的p.Ser496Pro变异,作为与异常矿化和超数牙相关的潜在候选者.
结论:
- 这个案例突出了有效的正牙策略,用于管理复杂的牙异常.
- 鉴定到的TCF7L2基因变异为非综合征超数牙的分子基础提供了新的见解.
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