一篇评论:基于脂质的药物输送系统的表面工程
Dhaval Patel1, Jyoti Solanki2, Mafatlal M Kher1
1Department of Chemical Engineering and Biotechnology, Ariel University, Ariel, 4070000, Israel.
Small (Weinheim an der Bergstrasse, Germany)
|July 15, 2024
概括
表面修饰增强了基于脂质的纳米粒子 (LBNPs) 用于药物输送. 本综述详细介绍了修改LBNPs和基于细胞膜的纳米粒子 (CMNPs) 的进展,以改善准和生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 基于脂质的纳米颗粒 (LBNPs) 对于药物输送 (DD) 是至关重要的.
- 传统的LBNP面临着一些挑战,如目标不佳,快速清除和有限的生物相容性.
- 表面修饰提供了一个有希望的策略来克服这些局限性.
研究的目的:
- 审查用于药物输送的LBNP表面修饰的演变和进展.
- 探索基于细胞膜的纳米粒子 (CMNPs) 和生物模拟混合纳米粒子,以增强DD.
- 为基于脂质的DD系统的研究人员提供全面的资源.
主要方法:
- 将LBNP分为脂质体和CMNP的分类.
- 分析各种表面修饰材料 (例如,PEG,体,体,天然体).
- 探索来自各种细胞类型 (红细胞,血小板,白细胞,癌细胞,干细胞) 的CMNP.
- 通过细胞膜涂层对仿生混合纳米粒子进行讨论.
主要成果:
- 表面修改显著增强LBNP的特性,包括大规模运输,免疫逃避,稳定性和准.
- 对于有效的DD,CMNP利用了自然细胞的特性,如生物相容性和免疫逃避.
- 生物模拟混合纳米粒子将合成NP的优势与细胞膜的优势相结合.
结论:
- 表面修饰和CMNP的使用代表了基于脂质的药物输送的关键进步.
- 这些策略提供了更好的治疗效果和减少副作用.
- 该审查强调了基于脂质的DD系统的动态进展和未来方向.
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