在基尿素疗法下皮肤皮质炎样皮肤喷发隐藏TP53突变的非典型皮细胞:一个基因病理学和分子病理学病例系列
Wiebke Pruessmann1, Jutta Kirfel2, Verena-Wilbeth Sailer2
1Department of Dermatology, University of Lübeck, Lübeck, Germany.
Journal of cutaneous pathology
|July 15, 2024
概括
长期的氧尿素疗法可能会导致罕见的"皮肤肌炎样"皮肤病变. 这些独特的喷发可能源于对角质细胞变化的炎症反应,可能与TP53突变和增加皮肤癌风险有关.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 基尿素是一种用于骨髓增殖性疾病的DNA合成抑制剂.
- 长期的基尿素治疗很少会诱导"皮肤肌炎 (DM) 样"的皮肤病变.
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