老年霍奇金淋巴瘤患者的治疗方法
Paul J Bröckelmann1,2,3
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD).
Current opinion in oncology
|July 15, 2024
概括
患有霍奇金淋巴瘤 (HL) 的老年人面临治疗挑战. 像尼沃卢马布这样的新疗法显示出希望,但仔细的患者选择是这个异质群体最佳结果的关键.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 老年医学 老年医学
背景情况:
- 霍奇金淋巴瘤 (HL) 呈现双模式年龄峰值,老年人 (≥60岁) 包含一个显著和异质的患者群体.
- 较老的HL患者往往有并发症和不同的健康水平,导致治疗结果比年轻人差.
研究的目的:
- 总结一下被诊断患有霍奇金淋巴瘤的老年患者不断发展的治疗环境.
- 审查目前和新兴的治疗策略,以适应老年HL患者的独特挑战.
主要方法:
- 对老年人霍奇金淋巴瘤治疗的当前文献的综述.
- 对最近的临床试验数据和有关老年HL患者的药物批准的分析.
主要成果:
- 对于有限阶段HL的第一线治疗仍然主要是ABVD化疗和放射治疗.
- 布伦图西马布维多丁加AVD (BV-AVD) 显示,由于毒性和缺乏生存益处,在老年人中使用有限.
- 尼沃卢马布加AVD (N-AVD) 在60岁以上患者的晚期HL中显示出有前途的早期结果.
- 二线选择包括高剂量化疗与干细胞移植适合患者,和PD-1抑制剂不适合或复发的个体.
结论:
- 越来越多的老年HL患者构成了重大的治疗挑战.
- 最近的进展和向性药物提供了新的希望,但仔细考虑患者的健康状况和并发症对于有效的管理至关重要.
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