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Updated: Jun 21, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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Published on: May 5, 2023

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人类转录媒介复合体的结构基础,其可分离的激酶模块调节了该复合体

Shin-Fu Chen, Ti-Chun Chao, Hee Jong Kim

    bioRxiv : the preprint server for biology
    |July 15, 2024
    PubMed
    概括

    CDK8激酶模块 (CKM) 通过阻断RNA聚合酶II (Pol II) 与中介体复合体结合来抑制转录. 结构洞察力揭示了CKM如何阻碍转录启动并影响启动后的基因表达.

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