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Updated: Jun 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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:一种编码蛋白质的圆形RNA,可调节BCR/ABL阳性白血病中DNA损伤反应

Dimitrios Papaioannou, Amog P Urs, Rémi Buisson

    bioRxiv : the preprint server for biology
    |July 15, 2024
    PubMed
    概括

    循环RNAcircPCMTD1通过增强DNA损伤耐受性来驱动白血病细胞的生长. 在BCR-ABL阳性白血病中抑制circPCMTD1通过破坏这种保护机制来延长生存时间.

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