Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

11.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
11.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effects of exercise on physical function and pain in adults with rheumatoid arthritis: an exit meta-analysis of randomized controlled trials.

Clinical rheumatology·2026
Same author

Authors' response.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Social determinants of health and epigenetic clocks: a systematic review and meta-analysis of 140 studies.

Nature human behaviour·2026
Same author

Immigrant Generation and Depressive Symptom Trajectories from Early Adolescence to Midlife: Evidence from Add Health.

Journal of health and social behavior·2026
Same author

A Lasting Legacy: Long-Term Effects of Exercise Training on Cardiometabolic Health in the STRRIDE-Prediabetes Reunion Study.

medRxiv : the preprint server for health sciences·2026

相关实验视频

Updated: May 2, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

25.5K

在基于DNA甲基化的工具中反映的Infinium MethylationEPIC v2.0和v1.0之间的读数差异:对人类人口表观遗传学研究的含义和考虑

Beryl C Zhuang1,2, Marcia Smiti Jude1,2, Chaini Konwar1,2

  • 1BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.

bioRxiv : the preprint server for biology
|July 15, 2024
PubMed
概括
此摘要是机器生成的。

新的Illumina MethylationEPIC BeadChip Infinium微阵列v2.0 (EPICv2) 显示了高阵列级相关性,但与EPICv1.1的可变探针级一致性. 版本差异对DNA甲基化工具产生影响,需要在研究中仔细协调.

关键词:
通过DNA甲基化.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.在Illumina的EPIC阵列中,细胞类型的解解.遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表炎症和生活方式生物标志物.复制探头进行复制.

更多相关视频

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.5K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K

相关实验视频

Last Updated: May 2, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

25.5K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.5K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K

科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 基因组学就是基因组学.
  • 生物技术是生物技术.

背景情况:

  • 伊卢米纳甲基化EPIC BeadChip Infinium微阵列v2.0 (EPICv2) 是一个新的DNA甲基化分析平台.
  • 它与前一个版本 (EPICv1) 的一致性在数组级别很高,但尚未完全评估下游基于DNA甲基化的工具.

研究的目的:

  • 调查EPICv1和EPICv2之间的一致性,用于基于DNA甲基化的工具,包括细胞类型解,表观遗传时钟和生物标志物.
  • 评估EPIC版本差异对这些工具的影响,并探索缓解策略.

主要方法:

  • 用EPICv1和EPICv2对来自四个成年队伍的匹配静脉血液样本进行了DNA甲基化分析.
  • 数据分析侧重于数组级和探针级一致性,以及版本差异对各种基于DNA甲基化的工具的影响.
  • 评估了标准化方法和版本调整策略.

主要成果:

  • 根据EPIC版本分组的样本,表明平台之间的系统差异.
  • 观察到高数组级一致性,但探针级一致性差异很大.
  • 基于DNA甲基化工具的估计显示出显著的版本特定差异,即使在正常化后.

结论:

  • 考虑EPIC版本对于研究至关重要,特别是在元分析和纵向研究中,这些研究涉及不同版本的样本.
  • 版本差异可能会影响全表观基因组关联研究 (EWAS) 的发现,特别是对于不太一致的探针.
  • 根据EPIC版本进行调整或单独分析每个版本的数据可以减轻不一致.