在精神分裂症和双极性障碍中对白物质的扩散基谱成像
Daniel Mamah1, Aakash Patel1, ShingShiun Chen1
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
bioRxiv : the preprint server for biology
|July 15, 2024
概括
精神分裂症 (SCZ) 涉及广泛的神经炎症和白质 (WM) 完整性下降,与双相情感障碍 (BPD) 不同. 扩散基谱成像 (DBSI) 揭示了这些大脑变化,可能有助于SCZ的早期干预.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经学 神经学
背景情况:
- 神经炎症与精神分裂症 (SCZ) 病理生理学有关.
- 很少有活体工具用于成像脑炎症.
- 扩散基谱成像 (DBSI) 评估白质 (WM) 病理中的微观结构变化.
研究的目的:
- 使用扩散基谱成像 (DBSI) 调查精神分裂症 (SCZ) 和双相情感障碍 (BPD) 中的白质 (WM) 微结构差异.
- 评估DBSI指标与SCZ中的临床症状之间的关系.
主要方法:
- 从27个对照组,21个SCZ和21名BPD参与者 (年龄在18-30岁) 获得的扩散MRI数据.
- 基于通道的应用空间统计 (TBSS) 用于全脑WM分析.
- 对比了DBSI衍生的扩散量,并将它们与临床症状相关联.
主要成果:
- 在WM中,SCZ显示DBSI衍生的细胞性增加 (神经炎症标志物),受限纤维分数减少 (轴突密度标志物),并增加了轴突外水 (瘤标志物).
- BPD 呈现出最小的 WM 异常,主要在体中.
- 在SCZ中,DBSI指标与精神病和情绪症状有显著的相关性.
结论:
- SCZ与普遍的WM神经炎症,纤维密度降低和脱髓化有关,在BPD中没有观察到.
- DBSI指标可能有助于识别高风险个体进行早期干预.
- 需要进一步的研究来探索药物效应.
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