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Updated: Jun 21, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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通过基突变和脂质进行TRPML1门调节

Ninghai Gan1,2, Yan Han2, Weizhong Zeng1,2

  • 1Howard Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

bioRxiv : the preprint server for biology
|July 15, 2024
PubMed
概括

研究人员在TRPML1通道中发现了关键残留物Tyr404,该残留物对于调节IV型粘脂症中其功能至关重要. 这个部位的突变为开发TRPML1激活剂和抑制剂创造了新的标.

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