Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

DNA Microarrays02:34

DNA Microarrays

17.3K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.3K
Genomics02:02

Genomics

36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K
Genetic Screens02:46

Genetic Screens

4.9K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.9K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.6K
Reporter Genes02:11

Reporter Genes

11.3K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
11.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Induction of subtle blood-brain barrier dysfunction using preclinical diagnostic ultrasound combined with microbubbles.

Fluids and barriers of the CNS·2026
Same author

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum.

bioRxiv : the preprint server for biology·2026
Same author

Ferroptotic neurodegeneration and diet: a narrative review.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Measuring blood-brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post-mortem approaches.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Therapeutic efficacy of extracellular vesicles from hiPSC-derived MSCs in serum-containing and xeno-free media for osteoarthritis treatment.

Stem cell research & therapy·2026
Same author

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.

bioRxiv : the preprint server for biology·2026
Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026
Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026
Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026
Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 21, 2025

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
08:00

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

7.5K

基因冲浪器使得转录组范围内的探索和基因共表达模块在3D空间转录组学数据中的功能性注释成为可能.

Chang Li1, Julian Thijssen1, Thomas Kroes1

  • 1Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

bioRxiv : the preprint server for biology
|July 15, 2024
PubMed
概括
此摘要是机器生成的。

基因冲浪器 (GeneSurfer) 是一种用于在3D空间数据中探索基因共同表达模式的新工具. 它有助于研究人员在大型数据集中找到和理解局部基因活动.

关键词:
空间转录组学 空间转录组学共同表达是一种共同表达.基因本体学 基因本体学这就是scRNA-seqq.视觉分析 视觉分析

更多相关视频

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.1K
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K

相关实验视频

Last Updated: Jun 21, 2025

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
08:00

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

7.5K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.1K
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K

科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 基因共同表达分析对于理解生物功能至关重要.
  • 现有的工具缺乏在大型数据集中进行本地化协同表达探索的能力.

研究的目的:

  • 介绍GeneSurfer,这是一个交互式界面,用于在3D空间领域探索本地化转录组范围内的基因共同表达模式.
  • 提供一个工具,促进识别和空间解析基因表达模式的注释.

主要方法:

  • 开发了GeneSurfer,这是一个具有基因过,空间聚类和3D可视化功能的交互式界面.
  • 综合性即时基因本体学 (GO) 术语注释用于共同表达的基因集.
  • 将该工具应用于空间转录组学和单细胞RNA测序数据,这些数据来自艾伦大脑细胞图谱.

主要成果:

  • 基因冲浪器 (GeneSurfer) 能够在3D空间数据中有效地探索局部基因共同表达.
  • 该工具成功地识别并注释了本地化转录基因组范围内的共同表达模式.
  • 在产生生物学见解和促进假设生成方面证明有用.

结论:

  • GeneSurfer解决了对局部基因共同表达的探索性分析工具的需求.
  • 该接口增强了对空间转录基因数据的调查.
  • 促进更深入地了解基因功能和在空间环境中的调节.