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Updated: Jun 21, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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TDP43自我调节导致缩短的异型,这些异型受到转录和后翻译机制的严格控制

Megan M Dykstra1, Kaitlin Weskamp2, Nicolás B Gómez3,4

  • 1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI.

bioRxiv : the preprint server for biology
|July 15, 2024
PubMed
概括

参与ALS和FTLD等神经退行性疾病的缩短TDP43 (sTDP43) 异型是由TDP43自我调节产生的,并由NMD清除. 过度表达sTDP43通过损害拼接和RNA结合导致神经退行.

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