热能刺激的代谢益处在衰老中得到保留
bioRxiv : the preprint server for biology
|July 15, 2024
概括
使用β3-上腺体激动剂的慢性热能刺激改善了老年小鼠的新陈代谢. 这种方法针对脂肪组织,以对抗与年龄相关的代谢功能障碍和肥胖.
科学领域:
- 代谢生理学 代谢生理学
- 脂肪组织生物学 脂肪组织生物学
- 衰老研究研究 衰老研究
背景情况:
- 中年和老年人中肥胖的患病率很高,与年龄相关的发热反应下降限制了治疗选择.
- 脂肪热生成是代谢功能障碍的潜在目标,但其在老年人群中的有效性尚不清楚.
研究的目的:
- 通过β3-上腺体 (AR) 激动剂 (CL316,243) 对老年小鼠系统代谢和脂肪功能的慢性热能刺激的影响.
- 为了阐明色脂肪组织 (BAT) 和白色脂肪组织 (WAT) 在对β3-AR刺激的反应中产生热生成的细胞机制.
主要方法:
- 将CL316,243给18个月大的C57BL/6JN小鼠.
- 系统代谢参数的评估,包括脂肪质量,能量消耗,葡萄糖平衡和阿迪波金 (adipokine) 概况.
- 在BAT和WAT仓库中进行热生成,线粒体活动,脂质生成和蛋白质表达的细胞分析.
主要成果:
- 持续的β3-AR治疗减少了脂肪质量,增加了能量消耗,增强了脂肪酸氧化和脂肪储存中的线粒体活动.
- 在BAT中,CL316,243改善了葡萄糖稳态和脂蛋白配置,增加了脱蛋白1 (UCP1) 依赖的热生成.
- 在WAT中,CL316,243诱导了UCP1独立的脂质生成和脂质循环,以及参与甘油代谢和再化中的蛋白质的上调调节,对炎症有剂量依赖的影响.
结论:
- 慢性β3-AR刺激激活了BAT和WAT中不同的细胞机制,以增强能量消耗和改善老年小鼠的全身代谢.
- 这项研究提供了针对脂肪热生成作为解决与年龄相关的代谢功能障碍和肥胖症的策略的证据.
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