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Updated: Jun 21, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

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艾滋病毒-1利用LEDGF在转录中的作用来定位整合

Rakesh Pathak, Caroline Esnault, Rajalingam Radhakrishnan

    bioRxiv : the preprint server for biology
    |July 15, 2024
    PubMed
    概括

    透镜上皮衍生的生长因子 (LEDGF) 将RNA聚合酶II招募到活性促进体,促进HIV-1跨基因的整合. LEDGF的双重作用解释了其参与MLL1驱动型白血病的原因.

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    Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein09:53

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