自我报告的睡眠不足与精神疾病中长期白质T2放松有关
Haluk Umit Yesilkaya1,2, Xi Chen1,3, Lauren Watford1
1McLean Hospital, Belmont, MA.
bioRxiv : the preprint server for biology
|July 15, 2024
概括
睡眠质量差与精神分裂症和双相情感障碍中的白质异常有关. 这表明睡眠障碍可能导致这些精神病障碍中的大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 呈现白质 (WM) 异常,但它们与疾病呈现的联系尚不清楚.
- 睡眠障碍在SZ和BD中很普遍,新出现的证据表明睡眠在WM生理学中起着至关重要的作用.
- 这项研究调查了睡眠障碍与精神病障碍中肌肉整合性受损之间的潜在关联.
研究的目的:
- 为了检查自我报告的睡眠障碍与白质 (WM) 横向 (T2) 放松时间之间的关系.
- 在被诊断患有精神分裂症谱系障碍和具有精神病特征的双相情感障碍的患者中调查这种关联.
主要方法:
- 招募了28名精神病患者 (17名精神病特征的BD-I,11名SZ频谱障碍).
- 在前面的冠状辐射中测量了代谢物和水T2放松时间,使用4TMRI.
- 使用匹兹堡睡眠质量指数 (PSQI) 评估睡眠质量.
主要成果:
- 在PSQI总得分和水T2放松时间 (r = 0.64,p<0.001) 之间发现了中等到强的正相关性.
- 线性回归研究证实,这种关联与睡眠障碍密切相关,独立于抑郁症,躁狂症或精神病症状.
- 探索性分析表明,睡眠障碍与增加的自由水百分比之间存在相关性,这表明涉及细胞外水的潜在机制.
结论:
- 这些发现强调了睡眠不足和精神疾病中白质异常之间的显著联系.
- 使用客观睡眠测量和先进的神经成像技术 (例如,免费水成像) 的进一步研究是有必要的.
- 这项研究为精神分裂症和双相情感障碍中睡眠障碍的神经生物学基础提供了新的见解.
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