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在COVID-19的治疗中Andrographis paniculata提取物与安慰剂对比:双盲随机对照试验

Puritat Kanokkangsadal^1,2, Chatchai Mingmalairak³, Nichamon Mukkasombat^1,2

¹Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.

Research in pharmaceutical sciences

|July 15, 2024

概括

在轻度病例中,Andrographis paniculata乙醇提取物 (APE) 并没有减少COVID-19的进展. 然而,APE显著缓解了头痛和嗅觉丧失症状,而不会引起不良影响.

科学领域:

药理学药理学是指药理学的学科.
临床医学临床医学
草药是一种草药.

背景情况:

安德罗格拉菲斯 (Andrographis paniculata) 已被建议用于缓解COVID-19的症状.
一项临床研究调查了其乙醇提取物 (APE) 的疗效和安全性.

研究的目的:

评估APE在无症状或轻度症状的COVID-19患者中的疗效和安全性.
在一项随机对照试验中,比较APE治疗与安慰剂.

主要方法:

进行了一项前性,双盲,随机对照试验.
患者接受APE (60毫克安德罗格拉福利德,每天3次,持续5天) 或安慰剂.
使用世卫组织的进展量表,症状评估和全球评估来评估有效性. 通过肝脏和功能测试来监测安全性.

主要成果:

165名患者完成了这项研究;83人接受了APE,82人接受了安慰剂.
在两组中,COVID-19症状在第5天显著改善,没有显著差异.
与安慰剂相比,APE在第一天显著减少了头痛,并在第二天显著减少了嗅觉损失.
在APE组中的80.7%的患者在5天内完全康复.
轻度腹是最常见的副作用,迅速消失. 没有观察到肝脏或脏毒性.

结论:

在轻度病例中,APE (180毫克/天5天) 并没有阻止COVID-19的进展.
APE在缩短嗅觉损失症状方面表现出显著的益处.
治疗被发现是安全的,在5天的时间内没有观察到肝脏或脏毒性.

关键词:

囊囊囊囊囊临床试验临床试验是指临床试验.新冠病毒新冠病毒新冠病毒.在HPLC中使用HPLC.

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