艾滋病毒感染者中的COVID-19疫苗和COVID-19
Muhammed Fatih Karaşın1, Zeynep Bayraktar1, Müge Toygar-Deniz1
1Department of Infectious Disease and Clinical Microbiology, Kocaeli University School of Medicine, Kocaeli, Türkiye.
Infectious diseases & clinical microbiology
|July 15, 2024
概括
接种COVID-19疫苗,特别是Comirnaty®疫苗,降低了HIV同时感染的人的感染率. 接种疫苗的艾滋病毒感染者的结局与没有艾滋病毒的人相似.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行引起了广泛的担忧,人类免疫缺陷病毒 (HIV) 携带个体的共同感染率显著增加.
- 了解疫苗接种对这一弱势群体COVID-19严重性的影响,对于公共卫生战略至关重要.
研究的目的:
- 评估COVID-19疫苗接种偏好和接种对HIV同时感染的患者SARS-CoV-2感染的严重程度的影响.
- 为了比较不同类型的疫苗 (Comirnaty®,CoronaVac®,混合) 在预防艾滋病毒感染者中严重的COVID-19的有效性.
主要方法:
- 一项回顾性研究包括205名接受HIV抗逆转录病毒治疗的患者,在2020年1月至2022年12月期间被诊断患有COVID-19.
- 通过rRT-PCR证实了COVID-19的诊断. 严重程度由住院标准来定义. 疫苗接种情况和人口统计数据从医院记录中收集.
主要成果:
- 与其他组相比,用Comirnaty®接种疫苗的患者在接种疫苗后的COVID-19感染率呈现出统计学上显著的降低 (p<0.05).
- 从接种疫苗到SARS-CoV-2阳性的平均时间有所不同:Comirnaty®为163天,CoronaVac®为149天,混合疫苗接种为154天.
结论:
- COVID-19 疫苗接种似乎有效地减轻了艾滋病毒感染者的感染严重程度.
- 接种疫苗的艾滋病毒感染者中,特别是那些感染控制良好的人中,COVID-19的临床过程和结果与没有艾滋病毒的普通人群中观察到的类似.
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