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克罗辛-脂复合物:分子对接,分子动力学模拟,制备,表征和抗氧化活性

Yasaman Rezaee1, Elham Rezaee2, Leila Karami3

  • 1Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian journal of pharmaceutical research : IJPR
|July 15, 2024
PubMed
概括

克罗辛-脂复合物 (CPC) 增强了克罗辛的作用.

关键词:
克罗辛克罗辛克罗辛克罗辛克罗辛克克罗辛克克罗辛克克罗辛克分子对接 分子对接分子动力学模拟模型脂化合物复合体 脂复合体可溶性 溶解度 可溶性 溶解度

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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