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在长期的1型糖尿病中,骨素,miR-143和miR-145的表达以及它们与HbA1c的相关性

Nabil A Hasona^1,2, Adel Abdel Moneim³, Esraa A Mohammed⁴

¹Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni Suef, 62511 Egypt.

Indian journal of clinical biochemistry : IJCB

|July 15, 2024

概括

这项研究确定了miR-143和miR-145作为1型糖尿病 (T1DM) 的潜在生物标志物. 这些微RNA的较低水平与T1DM相关,可以帮助预测疾病进展和并发症.

科学领域:

内分泌学和新陈代谢学
分子生物学分子生物学
生物标志物发现发现

背景情况:

糖尿病中高血糖会导致严重的并发症.
对于T1DM的早期检测和管理,需要新的生物标志物.
了解T1DM中的分子变化对于预测疾病进展至关重要.

研究的目的:

为了研究HbA1c,骨素,,和miR-143/miR-145表达在T1DM中的关系.
探索这些标志物在T1DM中的诊断潜力和相关性.
评估糖尿病持续时间如何影响这些生物标志物水平.

主要方法:

这是一项涉及90名T1DM患者和30名健康对照者的横截面研究.
将T1DM患者根据疾病持续时间 (<1年,1-8年,>8年) 分类为子组.
测量HbA1c,血清骨质卡尔辛,,,以及量化miR-143/miR-145表达水平.

主要成果:

与对照组相比,T1DM患者显示HbA1c升高,骨素,和水平降低.
在T1DM患者中观察到miR-143和miR-145的显著较低的表达水平.
所有测量参数的逐渐变化与糖尿病持续时间的增加,特别是在T1DM>8年的人群中.

结论:

miR-143和miR-145在T1DM中显著下调,并显示出作为新生物标志物的潜力.
这些microRNA可以作为T1DM进展和相关并发症的预测指标.
这项研究强调了这些microRNAs在理解T1DM病理生理学的有用性.

关键词:

这就是HbA1c.骨质素是一种骨质素.在T1DM中,它是T1DM.在 miR-14343 系统中,在 miR-14545 里面.

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