血清腺氨酸脱胺酶水平与肺结核肺结核的微生物参数的相关性
Krishna Sarkar1, Bineeta Kashyap1,2, Rajat Jhamb3
1Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, 110095 India.
Indian journal of clinical biochemistry : IJCB
|July 15, 2024
概括
血清腺脱氨酶与诊断肺结核的关键微生物参数有显著的相关性. 这种生物标志物可能有助于结核病患者的早期检测和治疗监测.
科学领域:
- 生物化学 生化学
- 微生物学 微生物学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 肺结核的准确诊断依赖于唾液显微镜,培养和GeneXpert MTB/RIF,但许多患者缺乏阳性唾液.
- 生物化学标志物对于早期结核病诊断,预防和评估药物反应至关重要.
研究的目的:
- 为了研究血清腺脱氨酶水平与肺结核患者的微生物参数之间的关联.
- 探索血清腺脱氨酶作为结核病诊断中的生物标志物的潜在实用性.
主要方法:
- 招募了40例通过Ziehl-Neelsen染色和/或CBNAAT诊断的肺结核病例.
- 在招募的患者中估计的血清腺脱氨酶水平.
- 分析了血清腺脱氨酶和唾液涂抹显微镜,培养结果和CBNAAT发现之间的相关性.
主要成果:
- 血清腺脱氨酶水平与年龄,唾液涂抹显微镜,培养阳性时间,CBNAAT类别和平均Ct值 (p <0.05) 有显著关联.
- 鉴定了血清腺氨酸脱氨酶和结核病确定的微生物诊断参数之间的显著相关性.
结论:
- 血清腺脱氨酶水平与用于诊断肺结核的几种微生物指标相关.
- 对血清腺脱氨酶的进一步研究可以提高结核病诊断和治疗策略.
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