在支气管镜检查前用利多卡因进行皮里格式内腔灌注对一般麻醉后咳的影响:一项随机对照试验
Keting Min1, Yu Wang1, Di Feng1
1Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Drug design, development and therapy
|July 15, 2024
概括
使用利多卡因的皮里形式内腔灌注有效地减少了经过支气管镜检查后的术后咳和喉痛. 这种简单的方法在早期康复期改善了患者的满意度.
科学领域:
- 麻醉学 麻醉学
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后咳是全身麻醉和支气管镜检查后的常见并发症.
- 确定有效的干预措施来缓解这种并发症对于患者的康复和满意度至关重要.
研究的目的:
- 评估用利多卡因进行皮里形式内腔灌注的有效性和安全性,以减少抽出后咳的发生率和严重程度.
- 评估这种干预对患者报告的结局 (如喉疼痛和整体满意度) 的影响.
主要方法:
- 一项随机对照试验,涉及88名接受支气管镜检查的患者.
- 患者接受了与2%的利多卡因或正常盐溶液 piriform 沉积灌注.
- 结果包括咳发病率,咳严重程度 (视觉模拟量表),喉疼痛得分 (数值评分量表),康复质量得分 (QoR-40) 和患者满意度.
主要成果:
- 利多卡因组的咳发病率显著降低 (63.6% vs 86.4%,P=0.014) 和减少咳的严重程度在10分钟后输出管.
- 接受利多卡因治疗的患者在10分钟内报告了明显较低的喉痛得分 (P<0.001) 和更高的整体麻醉满意度 (P<0.001).
- 喉痛,咳严重程度或24小时QoR-40的6小时后输出管后的组之间没有发现显著差异.
结论:
- 使用利多卡因的Piriform recess灌注是一种安全有效的方法,用于减少经过支气管镜检查后的早期术后咳和喉疼痛.
- 对咳和喉疼痛的好处在早期康复阶段 (输出管后10分钟内) 最明显.
- 进一步的研究可能会探索这种干预的长期影响或最佳时间.
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