在患有不同宫病变的患者中,C-myc表达,BMI-1表达和阴道微生态与HPV-DNA负载之间的相关性
Yingzhen Zhou1, Junfei Zhu1, Hao Zhang2
1Department of Laboratory, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine Suzhou 215000, Jiangsu, China.
American journal of translational research
|July 15, 2024
概括
在宫病变中,C-myc和BMI-1原瘤基因的高表达与增加的人类乳头瘤病毒-DNA (HPV-DNA) 负载和改变的阴道微生态相关. 这些发现表明C-myc和BMI-1在宫病进展中的作用.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 微生物学 微生物学
背景情况:
- 宫病变,包括宫内皮质瘤 (CIN) 和宫平细胞癌 (CSCC),与人类乳头瘤病毒 (HPV) 感染有关.
- 原型瘤基因C-myc和BMI-1涉及到细胞增殖和癌症的发展.
- 阴道微生态的改变可能会影响宫疾病的发展和进展.
研究的目的:
- 调查C-myc和BMI-1原基因表达,阴道微生态和HPV-DNA负载在患有不同宫病变的患者之间的相关性.
- 了解这些因素在宫病变的进展中的潜在作用.
主要方法:
- 对173名患者的回顾性分析分为CSCC,CIN和正常子宫 (NC) 组.
- 使用混合捕获2 (hc2) 检测HPV-DNA负载.
- 通过免疫组织化学评估C-myc和BMI-1表达.
- 在各组之间比较阴道微生态指标 (乳酸菌,白细胞化酶,pH).
主要成果:
- 与CIN和NC组相比,CSCC中的HPV-DNA负载和C-myc/BMI-1表达率更高 (P<0.05).
- 在CSCC组中减少了乳酸菌检测和增加了白细胞酶阳性和pH≥4.6.
- 在所有样本中,C-myc/BMI-1分数和HPV-DNA负载之间存在显著的正相关性.
结论:
- 在患有CIN和CSCC的患者的宫组织中,C-myc和BMI-1的表达很高.
- 在宫病变的患者中观察到阴道微生态的改变.
- 这些因素可能在宫病变的进展中起着重要作用.
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